I take it once a week to save on cost rather than taking it daily. It works directly, and the effects persists after use. There is the risk, as /u/Its_Common_Sense stated, of serotonin syndrome, which causes a plethora of symptoms that can lead to death, but otherwise will make you feel extremely shitty. From novel/alternative substances, to established medications. Thanks. That said, little research has been done on what the appropriate dosage should be. share. It is made from the amino acid known as arginine. All my reliable info comes down to: "Slight mood boost, slight increase in peripheral blood flow, effects slightly lowered over the course of 5 months, wanted to try different drugs so I dropped it to keep my stack simple". The B-Complex shouldn't (I'm not a professional) cause any interaction, but again, consult with the professional. [127] Depression also appears to be associated with perturbed imidazoline receptor signalling. Moderate dosages, though slightly less potent that depression drugs such as Tofranil (imipramine), show a promising ability to improve mood and reduce anxiety. I use bulk agmatine and citruline malate by AI Sports, because then I can actually get 6-8g of citruline malate and 1g of Agmatine that way. It works synergistically with numerous antidepressants. Take 1600mg of Piracetam and 300mg Alpha-GPC. Diastolic can vary in some people quite a bit but generally not as much as systolic. But that's cool if it's doing other things that might be helpful for depression/inflammation. I take it at night as I thought it was supposed to help with sleep. But being on only 150 mg of Wellbutrin was really not doing my brain very well at all - brain fog, headaches, not wanting to get out of bed. I'd take ketamine over agmatine any day. Agmatine Sulfate is readily available in capsule and powder form. otherwise I've done 2 scoops of Iforce Hemavol and that worked great. It’s a metabolite of the amino acid arginine and is created and stored in many organs, including the brain. Rhodiola off Amazon, the NOW brand. Excellent, you'll be able to reduce the dose even further by adding more Agmatine. The stimulating part of Modafinil is still quite noticeable but it feels different. It's worked great for me to boost the mood-enhancing effects of bupropion and to take the edge off any speedy feelings it can produce. Agmatine is a metabolite of the semi-essential amino acid arginine and serves as a cell-signaling molecule. It was noticeable after a couple of days. Placebo or not I an damn happy with how I reacted. The site may not work properly if you don't, If you do not update your browser, we suggest you visit, Press J to jump to the feed. “Started Wellbutrin 150 three years ago for depression, worked great, lost about 15 pounds in 6 months. Hello all, I'm new to nootropics and had a quick question. Agmatine appears to have antidepressant qualities. I would not muck about with serotonin. hide. [1] [2] Clinical research involving agmatine is scarce, but many athletic professionals and scientific researchers promote agmatine as a safe, reliable sports enhancement supplement. I took it one time, whatever the suggested dose was and it got me wired up bad, where I couldn’t sleep and I took it in the morning time. Does Agmatine work synergistically with Wellbutrin XL? Been on it three weeks (100mgs the first week, then 200mgs the second week, finally 300mgs) and it hasn't seemed to help the depression. Agmatine as punchy as Ketamine for depression - posted in Mental Health: Agmatine produces antidepressant-like effects by activating AMPA receptors and mTOR signaling. I have found it to work really well. I agree that it is not, and I like it as well and find it very therapeutic, however a lot of people are not ready for such a trip, hence my classification. Introduction. Modafinil comes with absolutely no pleasant feelings for me, it just puts me in this zone. Whuuuuut? I am on Wellbutrin 100mg 3x a day. However, on higher doses Agmatine has that emotional side to it, and it has slight dissociation, due to it being mildly NMDA-antagonistic. https://www.reddit.com/r/Nootropics/comments/7ezn7q/substances_that_share_the_same_moa_as_ketamine/. Bulksupplements is the cheapest and best. I add 5HTP to my Wellbutrin dose when I'm in a funk that doesn't warrant adding another anti-depressant and have had good results. Most human-based testing has utilized 2.6 grams per day or slightly higher. Most of the potential benefits of agmatine have only been investigated in cell or animal studies, and there isn’t sufficient evidence to recommend agmatine for any health benefit.In all cases, a better studied alternative is available. I'm deleting my 1.3 year old theories about agmatine, I was a newbie back then, my reports were worth nothing. Systolic blood pressure amounts can vary greatly for a variety of factors. It takes two weeks to start feeling the full effects of Pira. In the brain Agmatine does not directly convert into Nitric Oxide like L Arginine does. Those who have used this, where did you purchase yours? Should I increase my dosage? Agmatine, also known as (4-aminobutyl)guanidine, is an aminoguanidine that was discovered in 1910 by Albrecht Kossel. It's been 2 weeks I'm taking agmatine at a low dose (450 mg). Agmatine Sulfate also provides a number of athletic benefits. Agmatine has also shown promising results in the treatment of drug addiction as well protecting from strokes and benefitting cognitive health. No. Wellbutrin is an antidepressant that may be used to treat Major Depressive Disorder (MDD) and Seasonal Affective Disorder (SAD). Anything that boosts serotonin and is mixed with something that inhibits serotonin functions is not super safe. I hope this helps, and I'll answer any questions. This is due to its positive impact on the nervous system. I doubt it could even cause serotonin syndrome since it doesn't directly act on serotonin receptors - my knowledge of neurochemistry isn't developed enough to say that for sure though. 0 1 13 minutes read. It's worked great for me to boost the mood-enhancing effects of bupropion and to take the edge off any speedy feelings it can produce. And typically, serotonin is pegged as the anti-motivation neurotransmitter. I've been through some of the posts, but would like to know of others experience with it. However does it also have upper type effects? Should I take it in the morning? You doctor chose not to. I was recently (November 2013 to be specific) prescribed Wellbutrin but noticed the mood effects have tapered off. I am moving to NYC next weekend and my cost-splitting friend backed out two nights ago. Common agmatine-containing foods include wine and beer. Awesome! Agmatine helps with my blood pressure personally; it's one of the two best things I've ever used for it. There are studies which cite that optimal dosages humans are in the 1.5g to 7.5g range. 76% Upvoted. Agmatine, an endogenous guanidine amine, has been shown to produce antidepressant-like effects in animal studies. Therefore … Continue reading Agmatine: an absolutely amazing amino acid for your whole body Sort by. As someone else stated, agmatine is awesome. I took 1g with 45mg of Nardil for a few weeks, no issues. New comments cannot be posted and votes cannot be cast. Unlike Kratom, Agmatine is an amino acid compound, which is also produced by our bodies. r/depressionregimens is a community focused on the research and discussion of treatments for depression and anxiety. Hemavol tastes great too - … I've sent her an email asking if adding Agmatine to my current dosages is okay. Very interesting if true. Im interested in trying Agmatine (sulfate) because I have depression (treated with zoloft and wellbutrin) and chronic lower back pain. The efficacy of Wellbutrin in the treatment of a major depressive episode was established in two 4-week controlled inpatient trials and one 6-week controlled outpatient trial of adult subjects with MDD [see Clinical Studies (14)]. [18][19] Research has found agmatine to be non-toxic when taken appropriately. Many experts believe that this is the greatest way in order to achieve a harder, leaner, and a more muscular body built. Agmatine is an interesting substance as it is specifically referenced as a great thing to take with Wellbutrin (bupropion). Wellbutrin (bupropion hydrochloride) is indicated for the treatment of major depressive disorder(MDD), as defined by the Diagnostic and Statistical Manual (DSM). Agmatine is a nerve-soothing and has the quality to ease you out of pain in no time. Potential Benefits of Agmatine. Other treatment modalities are welcome as long as there is a clear intention towards symptom improvement, and at least a modest attempt at being scientific. and do not have the psychedelic side effects such as ketamine. Here's the downside, HAIR-LOSS. (450 mg x 7 times a week is actually slightly more than your weekly 2,6 g). Agmatine is an endogenous amine synthesized via the decarboxylation of L-arginine mediated by arginine decarboxylase. Agmatine is an interesting substance as it is specifically referenced as a great thing to take with Wellbutrin (bupropion). I didn't rage- which felt totally out of character for me. The activation of AMPA receptors and mTOR signaling has been reported as mechanisms underlying the antidepressant effects of fast-acting agents, specially the NMDA receptor antagonist ketamine. Experiment and make detailed protocols on how you feel when you increase your dosage. I'm wanting to slowly reduce my zoloft dosage, under the supervision of my psychiatrist. Press question mark to learn the rest of the keyboard shortcuts. Agmatine is quickly replacing arginine as the go-to nitric oxide ingredient. Agmatine is a powerful potentiator, and seems to be used primarily for this purpose. Agmatine is considered to be a neurotransmitter and neuromodulator. You can read my personal testimony to it there, it is very powerful. I buy my noot powders from NootropicsDepot. It is stored in neurons and is released during neuronal activation. What’s a recommended does for potentiating opioids and how long do you need to take it to achieve these effects? What Is Agmatine? You can start with a simple piracetam/alpha-gpc stack. That gave me 1g of Agmatine + 5g of citruline malate. After taking both Moda and Agmatine together the effects of Modafinil seem different, in a good way. I have loss 1/3 of my hair, and enough was enough. [212]", http://www.ncbi.nlm.nih.gov/pubmed/23583442. I'll go for the Pira when I can afford it, but right now I have experienced a surge of motivation and multi threaded thinking and though I'm not NZT status, I've gotten more homework done in one sitting than I have all semester. I’ve read it’s also a supplement for weight training. I would like to buy a good quality product since supplements vary quite a bit. 750mg is my dose. [15][16][17] Agmatine also shows the ability to compliment usage of anti-depression drugs such as Wellbutrin (bupropion). Facebook Twitter LinkedIn Tumblr Pinterest Reddit WhatsApp. Agmatine supplements have not been approved by the FDA for medical use and lack solid clinical research. I have created a post about in the nootropics area along with other substances that share the same effect pharmalogical profile on the brain as ketamine and agmatine have. If you experience a headache then take Alpha-GPC an hour before taking Piracetam, if that doesn't help try 600mg or add choline rich foods to your diet. Also, Rhodiola Rosea works great by itself. The Definitive Guide to Agmatine Sulfate Supplementation. Yes, always take a B-complex. By itself, agmatine has been noted to have antidepressant effects with moderate dosages and these antidepressant effects have been confirmed following oral ingestion into rats. Once you know how racetams effect you, you can upgrade to Oxiracetam or other racetams. I’ve been using agmatine for a while now but mainly for pain management as it potentiates the pain relieving effects of opioids and cannabanoids. I’ve read it does potentiate opioids and so on and also lowers tolerance. Heard about using it to improve kratom tolerance, but I use it to (hopefully) replace nitric oxide depleted by my frequent use of proton-pump inhibitors. Being disentangled from the fabric of reality can be very therapeutic. In the excitement to learn all about agmatine’s muscle building benefits, however, the side effects conversation is usually tabled and never revisited. Try that for a few days. This includes improving and enhancing the body’s response to insulin. This thread is archived. I'm writing this on my phone so excuse my writing :). This sub is not for venting or for facebook style posts. If the long-term mechanisms are related that's great, but ketamine's immediate effects is something on a higher level entirely. Smart and informed Kratom users ... Read moreAgmatine Analysis and Experience It calms NMDA activity enough without making you spacey and it seems to click with wb. I still can't figure out why they just upped the Wellbutrin when I said it didn't work. I take 2-3 doses of 700mg Agmatine per day. ie, does it enhance or intensity the effects? Coupled up with Kratom, Agmatine helps combat chronic conditions to provide lasting tranquility. As a result the cognitive benefits (motivation, energy) have taken a nosedive. Discussion and anecdotes are welcome! 100-200mg for anti-fatigue, 300-600mg for anti-stress, anti-anxiety. Agmatine, is a substance that has existed since 1911 which posseses the same antidepressant effects as ketamine and other glutamergic drugs, by inducing massive neurogenesis in the prefrontal cortex & hippocampus via mTor signaling and AMPA receptor activation. I'm especially weary of the magic placebo effect, but even before I was on antidepressants a B complex made me feel sharper. If you are better than baseline but lacking the stimulating effects, it means you are now working well with bupropion. I haven't notice any effect yet. (I don't find it energising, but not sedative either at my dosage). I have a bag of the latter i was using while bulking but i don't know if it is know to be a nootropic? I hated the Wellbutrin. Those overstimulation effects are side effects, not the primary goal. It's not a side effect, it's what makes ketamine awesome. Key Takeaways. 100 grams of 4.5 star product on amazon is $15 maybe save some money there? I was upped to the 300mg Bupropin XL (of dubious bioequivalence) and after experiencing withdrawal symptoms, determined that serotonin reuptake may not be the issue at hand. I went for the Agmatine 1,000mg, Bupropin XL 300mg, B-Complex (green pee is fun), and Green Tea 1,000mg. Consult your doctor. save. There is presently a great interest in the therapeutic potential of agmatine, decarboxylated arginine, for various diseases. Wellbutrin is a brand name for bupropion. New comments cannot be posted and votes cannot be cast, More posts from the StackAdvice community, Press J to jump to the feed. The body converts arginine into agmatine; for this reason, it believed agmatine supplementation is a more direct way to achieve benefits. I suppose they have a preset cookie cutter flowchart. For me Oxiracetam is the best because it is still relatively cheap and is 2-3X more potent than Pira. Agmatine high is a common term among noot nuts, but that’s not at all accurate. Preliminary googling looks like it helps boost serotonin. I have a big bag of agmatine in my drawer! Is this dangerous to use with antidepressants and anti anxiety meds? admin 2 hours ago. Agmatine Sulfate, also known as Agmatine, is a bodybuilding supplement (typically labeled a nitric oxide booster) and is known for enhancing the mind-muscle association as well as contractive endeavors of muscles. Press question mark to learn the rest of the keyboard shortcuts. Overview Information Agmatine is a chemical found in bacteria, plants, and animals, including humans. Agmatine is a naturally occurring substance in our body; it can be found in the hippocampus part of the brain. Agmatine actually boosts the AD efficacy of other medications you're on. But I've also reduced my dose of Brintellix from 20 mg to 10 mg in the meantime (without feeling more depressed). Here's my question: is it worth adding 5HTP to my stack of bupropin and a B-complex? "Agmatine is also influenced by pharmaceutical depressants, being reduced in concentration by bupropion (Wellbutrin)[69] while SSRI drugs increase agmatine concentrations. So I emailed my doc and asked to go back on the full dose, which she said was fine for the time and maybe we could consider lowering at another point in my life. Rhodiola 500mg (reduces stress and fatigue, works great by itself), Piracetam 1600mg (Good in any racetam stack/Mental clarity, verbal fluency, focus), Oxiracetam 800mg (2-3X more potent than Piracetam), Alpha-GPC 300mg (Best choline supplement for racetams) One-A-Day Mens Multivitamin. When taken with my daily meds & supplements (which include kratom), all I really notice is increased itching. report. Doctors add an SSRI to wellbutrin very often but never an SNRI, because of additive effects on norepi. Looks like you're using new Reddit on an old browser. 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