Test INR 1-2 days prior to surgery. Stop oral anticoagulants at least 5 days preoperatively, and do not perform the procedure until the PT is in the reference range. Stop LMWH a minimum of 12 hours and UFH six hours before surgery. Stop Warfarin 4-5 days before surgery; Allow INR to decrease; Start Anticoagulation 2 days before surgery. High Bleeding Risk: Surgery involving major organs such as heart, neurosurgery, ophthalmologic, genitourinary, spine surgery, procedures requiring hemostasis (e.g. Stop warfarin 5 days prior to surgery; Have an INR 2 days after stopping the wafarin; You may need to start Clexane injections if your warfarin level is low (1.5) Your last dose of Clexane should be on the morning before your day of surgery. +1: Start warfarin as soon as oral fluids tolerated using the preoperative maintenance dose. Discontinue Heparin 6 hours prior to surgery. 2. Consult haematologist. Last pre-op dose: - Stop IV heparin 4 h pre-op - 50% total dose enoxaparin 24 h pre-op (e.g., AM dose of enoxaparin 24 h pre-op if q12h regimen) Moderate Stop warfarin 5 days pre-op. Dose: 1mg Protamine for every 100 units of heparin administered over the last 4 hours. One of the most occurring complications of major surgery is known as a DVT ( Deep Vein Thrombosis= blood clot). Heparin is discontinued 6-12 hours before surgery and restarted at 200-400 U/h at 4-6 hours after surgery. 1. Full dose Heparin or; Full dose Low Molecular Weight Heparin; Hold Heparin before surgery. Stop Warfarin 5 days before surgery to allow INR to normalise 2. spinal anesthesia) or when additional patient specific risk factors are present. If UFH required admit patient 3 days pre-operatively (use Trust Guideline: Use of intravenous heparin) Medication Class Medication Name When to Hold Before Surgery – Standard Bleeding Risk Coumadin (Warfarin) How many days BEFORE your surgery to stop taking this drug. If you need bridge (short-term) therapy with an injectable anticoagulant (blood-thinner) such as heparin, or a low molecular weight heparin such as enoxaparin (Lovenox). Perioperative Management of Heparin: 1. Discontinue UFH approximately five hours before surgery. It is given to prevent post operative complications, such as a blood clot that may occur in the lower legs or the calf area. If clotting risk is not low – You may not want to stop thinning your blood for too long. 2. Reassess INR on day of surgery. It is also possible to continue with subcutaneous UFH or LMWH and to stop therapy 12-24 hours before surgery… This dose should be half of your normal daily dose. Typically stop medications like rivaroxaban, apixaban and dabigatran 2-3 days before surgery. The Heparin injection that she was given prior to surgery, is usually a low dose amount Heparin. Bridge with treatment dose intravenous (IV) unfractionated heparin or subcutaneous (SC) enoxaparin. These are just estimated numbers and they change from patient to patient and from procedure to procedure. 5000 units subcutaneously 2 hours before surgery and 5000 units subcutaneously every 8 to 12 hours thereafter for 7 days or until the patient is ambulatory, whichever is longer. Slow intravenous injection of Protamine 1% solution. Reversal of Heparin Anticoagulation: 1. 0 (surgery day) Measure INR and if >2.0 on the morning of surgery, options include: postponement of surgery, fresh frozen plasma. Coumadin is restarted as soon as tolerated by the patient. ... -Patients receiving heparin continuous IV infusion: Stop heparin immediately after administering the first dose of oral anticoagulant. ; Herbal Products and Other Natural Supplements. Reorder Heparin 12 hours after surgery (if there is no evidence of bleeding) . Start treatment dose Dalteparin 3 days pre-operatively (prescribe 08.00h) ** Use Table 1 for Dalteparin dose. 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